# Chromatography Method Development AI Agent Connect

> Automate chromatography method selection, column recommendation, and resolution prediction.

## Overview
- **Category:** science
- **Price:** Free
- **Endpoint:** https://edge.vinkius.com/vk_preview_acVSPL06QGymX5QL6Gt8esocrOoC8kOk4HTlhmLk/ai-agent-connect
- **Tags:** hplc, gc, tlc, chromatography, analytical-chemistry

## Description

This MCP server provides a specialized toolkit for automating chromatographic method development across HPLC, GC, and TLC modalities. It allows AI agents to perform complex chemical calculations including `select_column` for stationary phase selection, `suggest_mobile_phase` for solvent optimization, `calculate_expected_resolution` for predicting peak separation, and `evaluate_method_feasibility` to ensure compatibility with specific detectors.

## Tools

### evaluate_method_feasibility
Assesses whether a proposed method is practical for a specific detection requirement

### calculate_expected_resolution
Predicts the separation quality between two specific analytes in a given method

### select_column
Recommends the most suitable stationary phase based on analyte properties and the chosen chromatography modality

### suggest_mobile_phase
Determines the optimal composition of the mobile phase to achieve separation

## Prompt Examples

**Prompt:** 
```
Recommend a column for a non-polar analyte with a molecular weight of 250 Daltons using HPLC.
```

**Response:** 
```
The recommended column for this non-polar analyte is a C18 bonded silica phase.
```

**Prompt:** 
```
What is the optimal mobile phase for a C18 column in HPLC with a target polarity that is moderately polar?
```

**Response:** 
```
The suggested mobile phase is an acetonitrile and water mixture with an organic ratio of 60%.
```

**Prompt:** 
```
Will a UV-Vis detector work for an analyte with these properties?
```

**Response:** 
```
Yes, the method is feasible for UV-Vis detection as the analyte contains suitable chromophores.
```

## Frequently Asked Questions

**Which chromatography modalities are supported?**
The server supports HPLC, GC, and TLC modalities.

**How can I predict if two analytes will separate well?**
You can use the `calculate_expected_resolution` tool to predict the separation quality between two specific analytes.

**Can I check if a detector is compatible with my method?**
Yes, the `evaluate_method_feasibility` tool assesses whether a proposed method is practical for a specific detection requirement.