# Validation Parameter Calculator AI Agent Connect

> Calculates ICH Q2 analytical method validation parameters like accuracy, precision, and linearity.

## Overview
- **Category:** science
- **Price:** Free
- **Endpoint:** https://edge.vinkius.com/vk_preview_1zJ0TvAnb6DTUjwUqzsUEUmKIy5yOWi5xAXCc5aa/ai-agent-connect
- **Tags:** ich-q2, analytical-chemistry, method-validation, accuracy, precision

## Description

This MCP server provides specialized tools for pharmaceutical and chemical method validation following ICH Q2 guidelines. It allows AI agents to perform complex analytical calculations including `calculate_accuracy` for percent recovery, `calculate_precision` for repeatability and intermediate precision, `calculate_linearity_and_range` for linear regression analysis, and `evaluate_method_suitability` to verify robustness and system suitability against defined thresholds.

## Tools

### calculate_accuracy
Calculates the accuracy of the method via percent recovery

### calculate_linearity_and_range
Validates the linear relationship between concentration and response

### calculate_precision
Evaluates the precision of the method across different levels

### evaluate_method_suitability
Checks if the method meets pre-defined acceptance criteria for robustness and system suitability

## Prompt Examples

**Prompt:** 
```
Calculate the accuracy for measurements [98.5, 101.2, 99.8] with a true value of 100.
```

**Response:** 
```
The percent recovery is 99.83%.
```

**Prompt:** 
```
Check the linearity for concentrations [10, 20, 30] and responses [5.1, 10.2, 14.9].
```

**Response:** 
```
The correlation coefficient is 0.999, confirming a strong linear relationship.
```

**Prompt:** 
```
Evaluate if the method is suitable with suitability results [0.98, 1.02] and robustness variations [0.01, 0.02] using thresholds {"suitability": 0.05, "robustness": 0.05}.
```

**Response:** 
```
The method is suitable as all parameters fall within the specified acceptance thresholds.
```

## Frequently Asked Questions

**Which guidelines does this tool follow?**
The calculations are designed to align with the International Council for Harmonisation (ICH) Q2 guidelines for analytical procedure validation.

**Can I calculate both repeatability and intermediate precision?**
Yes, by using `calculate_precision`, you can evaluate intra-day repeatability or inter-day intermediate precision depending on the input groups provided.

**How is linearity verified?**
The `calculate_linearity_and_range` tool calculates the correlation coefficient, slope, and intercept to confirm the linear relationship between concentration and response.