EPA Computational Toxicology MCP Server
Access the US EPA's CompTox Chemicals Dashboard data — search for chemicals, properties, hazard summaries, and exposure data.
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What is the EPA Computational Toxicology MCP Server?
The US EPA CompTox MCP Server gives AI agents like Claude, ChatGPT, and Cursor direct access to US EPA CompTox. Access the US EPA's CompTox Chemicals Dashboard data — search for chemicals, properties, hazard summaries, and exposure data. Powered by the Vinkius AI Gateway — no API keys, no infrastructure, connect in under 2 minutes.
US EPA CompTox MCP Server: see your AI Agent in action
Built-in capabilities (10)
get_bioactivity_summary
Retrieve a summary of high-throughput screening results from ToxCast/Tox21 assays
get_chemical_details
Get comprehensive metadata and identification details for a specific chemical using its DTXSID
get_chemical_lists
Identify which chemical lists (regulatory, research, or commercial) this chemical belongs to
get_chemical_synonyms
Retrieve all known synonyms and alternative names for a specific chemical
get_exposure_summary
Retrieve predicted exposure levels and product use data (ExpoCast/CPDat)
get_fate_and_transport
Retrieve environmental fate and transport data (e.g., half-life, bioconcentration)
get_hazard_summary
Retrieve a summary of toxicity values and hazard assessment data from ToxValDB
get_physicochemical_properties
Retrieve predicted and experimental physicochemical properties (e.g., melting point, logP, solubility) for a chemical
search_chemical_by_casrn
Search for chemicals by their CAS Registry Number (CASRN)
search_chemical_by_name
Search for chemicals by common, IUPAC, or synonym names in the EPA CompTox database
What this connector unlocks
Connect to the US Environmental Protection Agency's (EPA) Center for Computational Toxicology and Exposure (CCTE) and explore a massive repository of chemical data through natural conversation.
What you can do
- Chemical Search — Find substances by name, CAS Registry Number (CASRN), or DTXSID
- Physicochemical Properties — Retrieve melting points, boiling points, logP, and water solubility
- Hazard Assessments — Access toxicity values, NOAELs, and points-of-departure from ToxValDB
- Exposure Predictions — Explore predicted exposure levels and product use categories via ExpoCast and CPDat
- Bioactivity Screening — Analyze ToxCast/Tox21 high-throughput screening results for thousands of assays
- Environmental Fate — Check persistence, transport, and biodegradation metrics
How it works
1. Subscribe to this server
2. Enter your free EPA API Key (request it by emailing ccte_api@epa.gov)
3. Start investigating chemical safety and properties directly from your agent
This tool is essential for toxicologists, environmental scientists, and regulatory professionals who need instant access to high-quality chemical data.
Who is this for?
- Toxicologists — quickly gather hazard and bioactivity data for risk assessments
- Environmental Scientists — analyze fate and transport properties of contaminants
- Product Safety Teams — check chemical exposure and product use profiles
- Researchers — retrieve identifiers and synonyms for chemical lists
Frequently asked questions
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