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Use InterPro with your AI.

Connect your account once and let the AI you already use work with it, without building another integration. Classify protein sequences into families, predict functional domains, and explore evolutionary relationships across species.

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Works with modern AI clients that support MCP, including ChatGPT, Claude, Cursor, and more.

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Complete set · 16 capabilities

The complete InterPro capability set.

These are the exact actions your AI can choose when you ask it to work with InterPro.

Capability set01 / 04

01-04

4 capabilities in this set.

Part of 16 available through InterPro.

  1. 01

    Get cdd entry

    CDD provides curated models for protein domain families and includes additional alignment and structure data. Use accessions like cd00001. Get CDD (Conserved Domain Database) entry details

  2. 02

    Get clan

    Returns clan accession, name, description, and member counts. Use Pfam clan accessions like CL0001. Get Pfam clan (super-family grouping) details

  3. 03

    Get entry

    Returns name, type (family, domain, homologous superfamily, repeat, site), description, Gene Ontology terms, member database cross-references, and literature count. Use accessions like IPR000001, IPR036291. Get InterPro entry metadata for a family or domain

  4. 04

    Get entry taxonomy

    Returns taxonomy nodes with names, ranks, and protein counts. This answers the evolutionary biology question "which organisms have this domain/family?" and is essential for understanding protein evolution and conservation. Get taxonomic distribution of an InterPro entry

Capability set02 / 04

05-08

4 capabilities in this set.

Part of 16 available through InterPro.

  1. 05

    Get protein entries

    This is the key capability for understanding "what domains does my protein have?". the fundamental question in protein characterization. Get all InterPro entries matching a specific protein

  2. 06

    Get proteome

    Returns proteome ID, organism name, strain, reference status, and counters for associated entries and proteins. Use UniProt proteome IDs like UP000005640 (human). Get proteome details with domain coverage statistics

  3. 07

    List entry databases

    Shows the number of entries in each database. Useful for understanding the scope of available domain and family annotations. List all InterPro member databases and entry counts

  4. 08

    Search entries

    Optionally filter by entry type: family, domain, homologous_superfamily, repeat, or site. Returns accessions, names, types, and protein/structure counts. Use queries like "kinase", "zinc finger", "immunoglobulin". Search InterPro entries by keyword and type

Capability set03 / 04

09-12

4 capabilities in this set.

Part of 16 available through InterPro.

  1. 09

    Search proteins

    Returns UniProt accessions, names, lengths, organisms, and annotation counts. Use queries like "insulin", "hemoglobin", "BRCA1". Search proteins in InterPro by name or keyword

  2. 10

    Get entry proteins

    Returns protein accessions, names, lengths, and source organisms. Useful for finding all members of a protein family across the UniProt database. Get all proteins matching an InterPro entry

  3. 11

    Get entry structures

    Returns PDB IDs, names, experiment types, and resolutions. Useful for finding structural representatives of a protein family or domain. Get all PDB structures matching an InterPro entry

  4. 12

    Get pfam entry

    Pfam is the most widely used protein domain database. Use accessions like PF00069 (kinase domain), PF00076 (RRM domain). Get Pfam domain or family details

Capability set04 / 04

13-16

4 capabilities in this set.

Part of 16 available through InterPro.

  1. 13

    Get protein

    Returns the protein name, length, source organism, evidence level, fragment status, and counters for how many InterPro entries, Pfam domains, structures, and taxa are associated with it. Get protein details with all domain and family assignments

  2. 14

    Get structure

    Use a 4-character PDB ID like 1cbs or 4hhb. Get a PDB structure with mapped InterPro annotations

  3. 15

    Get taxonomy

    Returns the organism name, rank, lineage, number of children taxa, and counters for associated InterPro entries and proteins. Use IDs like 9606 (human), 10090 (mouse), 562 (E. coli). Get taxonomic node with entry and protein counts

  4. 16

    Search taxonomy

    Returns taxon IDs, names, ranks, and annotation counts. Use queries like "human", "drosophila", "arabidopsis", "saccharomyces". Search taxonomy by organism name

Observed, not estimated

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InterPro is checked daily against the live service.

Daily averagePeak 1190ms
Aug 21Today
Fastest day
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Slowest day
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14-day trend
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Connect your client

One URL. Every client.

Activate the Connector, copy your link, and paste it into the client you already use. 16 capabilities arrive ready to run.

Preview access · not provider authentication

The vk_preview_* token belongs to Vinkius preview infrastructure. It lets Claude discover and display the capabilities of InterPro, so you can see the experience inside your AI.

It does not authenticate your account with InterPro. Actions requiring credentials or live account data may not run until you activate the Connector and authorize the service.

InterPro Connector

You're all set. Choose your MCP client and follow the setup instructions.

Connector linkhttps://edge.vinkius.com/vk_preview_cBrAY2Gy2NSFguudqzcAnkyhKLGxzkfF44ThKH5h/mcp

Claude Desktop

Follow the steps below to connect in seconds.

  1. 1In Claude Desktop, open Settings → Connectors.
  2. 2Click “Add custom connector” and paste the connector link above as the remote MCP server URL.
  3. 3Click Add and start a new chat — InterPro capabilities are ready to use.
Configuration · claude_desktop_config.jsonCopy
{
  "mcpServers": {
    "ebi-interpro-mcp": {
      "url": "https://edge.vinkius.com/vk_preview_cBrAY2Gy2NSFguudqzcAnkyhKLGxzkfF44ThKH5h/mcp"
    }
  }
}
  • Claude
  • ChatGPT
  • Cursor
  • VS Code
  • Windsurf
  • Claude Code
  • JetBrains
  • Cline

Step-by-step instructions for each client are in the guide. How to connect

FAQ

Questions InterPro owners ask.

  • 01

    Do I need an API key?

    No. The InterPro API is completely public and requires no authentication. Enter any placeholder value in the API key field to activate the server immediately.

  • 02

    What databases does InterPro integrate?

    InterPro integrates 13+ member databases including Pfam (protein families), CDD (conserved domains from NCBI), SMART (signalling domains), Prosite (patterns and profiles), PANTHER (evolutionary classification), Gene3D (structural domains from CATH), HAMAP (microbial families), PRINTS (fingerprints), PIRSF (classification system), SFLD (superfamilies), and NCBIfam. This gives you a unified view of protein domain and family annotations from the world's leading classification resources.

  • 03

    Can I find which organisms have a specific protein domain?

    Yes. Use the get_entry_taxonomy capability with any InterPro accession to see the taxonomic distribution of that domain or family. This shows which organisms. from bacteria to humans. contain proteins with that specific domain. It is one of the most powerful capabilities for evolutionary biology, revealing how protein domains have been conserved or diversified across the tree of life.

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