Do I need an API Key or registration?

No. ClinicalTrials.gov is a fully public service maintained by the US National Library of Medicine. All data is accessible without any authentication.

What types of studies can I search for?

The database covers interventional trials (testing drugs, devices, procedures), observational studies, and expanded access programs. You can search across all phases, from early Phase 1 research to post-market Phase 4 surveillance.

Is the trial recruiting status updated in real time?

The data reflects what is currently published on the ClinicalTrials.gov database. Sponsors typically update the registry directly, so you will see the latest status logged in their system.

ClinicalTrials.gov MCP Server for OpenAI Agents SDK 3 tools — connect in under 2 minutes

Name: ClinicalTrials.gov
Availability: InStock
Author: Vinkius

openai.github.io/openai-agents-python/mcp

Built by Vinkius GDPR 3 Tools SDK

The OpenAI Agents SDK enables production-grade agent workflows in Python. Connect ClinicalTrials.gov through the Vinkius and your agents gain typed, auto-discovered tools with built-in guardrails — no manual schema definitions required.

Get MCP Server for AI Agents

ASK AI ABOUT THIS MCP SERVER

Open in ChatGPT Open in Claude Open in Perplexity

Vinkius supports streamable HTTP and SSE.

python

import asyncio
from agents import Agent, Runner
from agents.mcp import MCPServerStreamableHttp

async def main():
    # Your Vinkius token — get it at cloud.vinkius.com
    async with MCPServerStreamableHttp(
        url="https://edge.vinkius.com/[YOUR_TOKEN_HERE]/mcp"
    ) as mcp_server:

        agent = Agent(
            name="ClinicalTrials.gov Assistant",
            instructions=(
                "You help users interact with ClinicalTrials.gov. "
                "You have access to 3 tools."
            ),
            mcp_servers=[mcp_server],
        )

        result = await Runner.run(
            agent, "List all available tools from ClinicalTrials.gov"
        )
        print(result.final_output)

asyncio.run(main())

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About ClinicalTrials.gov MCP Server

The ClinicalTrials.gov MCP Server connects your AI agent to the United States National Institutes of Health (NIH) clinical research database — the gold standard for clinical trial transparency worldwide.

The OpenAI Agents SDK auto-discovers all 3 tools from ClinicalTrials.gov through native MCP integration. Build agents with built-in guardrails, tracing, and handoff patterns — chain multiple agents where one queries ClinicalTrials.gov, another analyzes results, and a third generates reports, all orchestrated through the Vinkius.

Core Capabilities

Universal Trial Search — Query over 500,000 registered studies by condition, drug name, sponsor, or any keyword. Filter by recruitment status and trial phase to pinpoint exactly what matters.
Deep Trial Profiles — Retrieve full study protocols including eligibility criteria, enrollment targets, intervention details, and sponsor information for any registered trial.
Active Recruitment Finder — Dedicated tool for patients and clinicians to discover trials actively enrolling participants right now, searchable by medical condition.

Zero authentication required. Fully open public data maintained by the National Library of Medicine. Critical for pharmaceutical researchers, healthcare professionals, patient advocates, and biotech analysts.

The ClinicalTrials.gov MCP Server exposes 3 tools through the Vinkius. Connect it to OpenAI Agents SDK in under two minutes — no API keys to rotate, no infrastructure to provision, no vendor lock-in. Your configuration, your data, your control.

How to Connect ClinicalTrials.gov to OpenAI Agents SDK via MCP

Follow these steps to integrate the ClinicalTrials.gov MCP Server with OpenAI Agents SDK.

Install the SDK

Run pip install openai-agents in your Python environment

Replace the token

Replace [YOUR_TOKEN_HERE] with your Vinkius token from cloud.vinkius.com

Run the script

Save the code above and run it: python agent.py

Explore tools

The agent will automatically discover 3 tools from ClinicalTrials.gov

Why Use OpenAI Agents SDK with the ClinicalTrials.gov MCP Server

OpenAI Agents SDK provides unique advantages when paired with ClinicalTrials.gov through the Model Context Protocol.

Native MCP integration via `MCPServerSse` — pass the URL and the SDK auto-discovers all tools with full type safety

Built-in guardrails, tracing, and handoff patterns let you build production-grade agents without reinventing safety infrastructure

Lightweight and composable: chain multiple agents and MCP servers in a single pipeline with minimal boilerplate

First-party OpenAI support ensures optimal compatibility with GPT models for tool calling and structured output

ClinicalTrials.gov + OpenAI Agents SDK Use Cases

Practical scenarios where OpenAI Agents SDK combined with the ClinicalTrials.gov MCP Server delivers measurable value.

Automated workflows: build agents that query ClinicalTrials.gov, process the data, and trigger follow-up actions autonomously

Multi-agent orchestration: create specialist agents — one queries ClinicalTrials.gov, another analyzes results, a third generates reports

Data enrichment pipelines: stream data through ClinicalTrials.gov tools and transform it with OpenAI models in a single async loop

Customer support bots: agents query ClinicalTrials.gov to resolve tickets, look up records, and update statuses without human intervention

ClinicalTrials.gov MCP Tools for OpenAI Agents SDK (3)

These 3 tools become available when you connect ClinicalTrials.gov to OpenAI Agents SDK via MCP:

find_recruiting_trials

Useful for patients and healthcare providers looking for active enrollment opportunities. Find clinical trials that are actively recruiting participants for a specific medical condition

get_trial_details

Retrieve full details of a specific clinical trial by its NCT identifier

search_clinical_trials

Can filter by recruitment status and trial phase. Search the ClinicalTrials.gov database for studies by keyword, condition, drug name, or sponsor

Example Prompts for ClinicalTrials.gov in OpenAI Agents SDK

Ready-to-use prompts you can give your OpenAI Agents SDK agent to start working with ClinicalTrials.gov immediately.

"Are there any clinical trials recruiting participants for Alzheimer's disease right now?"

"Show me Phase 3 trials related to breast cancer treatment."

"Get me the full details for trial NCT04280705."

Troubleshooting ClinicalTrials.gov MCP Server with OpenAI Agents SDK

Common issues when connecting ClinicalTrials.gov to OpenAI Agents SDK through the Vinkius, and how to resolve them.

MCPServerStreamableHttp not found

Ensure you have the latest version: pip install --upgrade openai-agents

Agent not calling tools

Make sure your prompt explicitly references the task the tools can help with.

ClinicalTrials.gov + OpenAI Agents SDK FAQ

Common questions about integrating ClinicalTrials.gov MCP Server with OpenAI Agents SDK.

How does the OpenAI Agents SDK connect to MCP?

Use MCPServerSse(url=...) to create a server connection. The SDK auto-discovers all tools and makes them available to your agent with full type information.