UniProt MCP Server
Search 250M+ protein sequences with functional annotations, gene names, subcellular locations, and amino acid data from the world's most comprehensive protein knowledge base.
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What is the UniProt MCP Server?
The UniProt MCP Server gives AI agents like Claude, ChatGPT, and Cursor direct access to UniProt via 3 tools. Search 250M+ protein sequences with functional annotations, gene names, subcellular locations, and amino acid data from the world's most comprehensive protein knowledge base. Powered by the Vinkius - no API keys, no infrastructure, connect in under 2 minutes.
Built-in capabilities (3)
Tools for your AI Agents to operate UniProt
Ask your AI agent "Tell me about the p53 tumor suppressor protein and its function." and get the answer without opening a single dashboard. With 3 tools connected to real UniProt data, your agents reason over live information, cross-reference it with other MCP servers, and deliver insights you would spend hours assembling manually.
Works with Claude, ChatGPT, Cursor, and any MCP-compatible client. Powered by the Vinkius - your credentials never touch the AI model, every request is auditable. Connect in under two minutes.
Why teams choose Vinkius
One subscription gives you access to thousands of MCP servers - and you can deploy your own to the Vinkius Edge. Your AI agents only access the data you authorize, with DLP that blocks sensitive information from ever reaching the model, kill switch for instant shutdown, and up to 60% token savings. Enterprise-grade infrastructure and security, zero maintenance.
Build your own MCP Server with our secure development framework →Vinkius works with every AI agent you already use
…and any MCP-compatible client
UniProt MCP Server capabilities
3 toolsGet full protein details by UniProt accession ID
Returns protein name, gene, organism, function, subcellular location, and sequence. Try: insulin, hemoglobin, p53, BRCA1, spike protein. Search UniProt for proteins by name, function, or keyword
Returns all protein isoforms and their functional annotations. Find proteins encoded by a specific gene
What the UniProt MCP Server unlocks
Connect your AI agent to UniProt — the Universal Protein Resource — the world's definitive knowledge base for protein sequence and functional information.
What you can do
- Protein Search — Find proteins by name, gene symbol, function, or organism across 250M+ entries from both TrEMBL (auto-annotated) and Swiss-Prot (manually curated)
- Accession Lookup — Get complete protein data by UniProt accession number (e.g., P04637 for human p53) including function, subcellular location, and full amino acid sequence
- Gene Search — Find all proteins encoded by a specific gene name across multiple organisms to compare orthologs and paralogs
How it works
1. Subscribe to this server
2. Start searching proteins immediately — no API key required
Who is this for?
- Molecular Biologists — quickly look up protein functions, domains, and post-translational modifications for experimental design
- Bioinformaticians — retrieve protein sequences and annotations programmatically for large-scale comparative analyses
- Drug Discovery Teams — identify therapeutic targets by searching protein functions and disease associations
Frequently asked questions about the UniProt MCP Server
What is the difference between Swiss-Prot and TrEMBL entries?
Swiss-Prot contains 570K+ entries that have been manually reviewed and curated by expert biologists — the gold standard for protein annotation. TrEMBL contains 250M+ entries that are computationally annotated from gene sequences. Swiss-Prot entries are marked as 'reviewed' and are highly reliable; TrEMBL entries are automatically generated and may contain errors.
Do I need to register or pay for an API key?
No. UniProt REST API is completely free and open without any authentication. There are no rate limits for reasonable usage patterns. UniProt is funded by the National Institutes of Health (NIH), European Molecular Biology Laboratory (EMBL), and the Swiss Institute of Bioinformatics (SIB).
Can I retrieve full amino acid sequences for proteins?
Yes. Every protein entry includes the full amino acid sequence with length information. The sequence is returned in standard one-letter amino acid code. For very large proteins (10,000+ residues), the sequence may be truncated in the response but the full accession data is always provided for direct download.
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Connect UniProt with your favorite client
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Give your AI agents the power of UniProt MCP Server
Production-grade UniProt MCP Server. Verified, monitored, and maintained by Vinkius. Ready for your AI agents — connect and start using immediately.