What is the difference between Swiss-Prot and TrEMBL entries?

Swiss-Prot contains 570K+ entries that have been manually reviewed and curated by expert biologists — the gold standard for protein annotation. TrEMBL contains 250M+ entries that are computationally annotated from gene sequences. Swiss-Prot entries are marked as 'reviewed' and are highly reliable; TrEMBL entries are automatically generated and may contain errors.

Do I need to register or pay for an API key?

No. UniProt REST API is completely free and open without any authentication. There are no rate limits for reasonable usage patterns. UniProt is funded by the National Institutes of Health (NIH), European Molecular Biology Laboratory (EMBL), and the Swiss Institute of Bioinformatics (SIB).

Can I retrieve full amino acid sequences for proteins?

Yes. Every protein entry includes the full amino acid sequence with length information. The sequence is returned in standard one-letter amino acid code. For very large proteins (10,000+ residues), the sequence may be truncated in the response but the full accession data is always provided for direct download.

UniProt MCP Server for Google ADK 3 tools — connect in under 2 minutes

Name: UniProt
Availability: InStock
Author: Vinkius

google.github.io/adk-docs/tools/mcp-tools

Built by Vinkius GDPR 3 Tools SDK

Google Agent Development Kit (ADK) is Google's framework for building production AI agents. Add UniProt as an MCP tool provider through the Vinkius and your ADK agents can call every tool with full schema introspection.

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Vinkius supports streamable HTTP and SSE.

python

from google.adk.agents import Agent
from google.adk.tools.mcp_tool import McpToolset
from google.adk.tools.mcp_tool.mcp_session_manager import (
    StreamableHTTPConnectionParams,
)

# Your Vinkius token — get it at cloud.vinkius.com
mcp_tools = McpToolset(
    connection_params=StreamableHTTPConnectionParams(
        url="https://edge.vinkius.com/[YOUR_TOKEN_HERE]/mcp",
    )
)

agent = Agent(
    model="gemini-2.5-pro",
    name="uniprot_agent",
    instruction=(
        "You help users interact with UniProt "
        "using 3 available tools."
    ),
    tools=[mcp_tools],
)

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About UniProt MCP Server

Connect your AI agent to UniProt — the Universal Protein Resource — the world's definitive knowledge base for protein sequence and functional information.

Google ADK natively supports UniProt as an MCP tool provider — declare the Vinkius Edge URL and the framework handles discovery, validation, and execution automatically. Combine 3 tools with Gemini's long-context reasoning for complex multi-tool workflows, with production-ready session management and evaluation built in.

What you can do

Protein Search — Find proteins by name, gene symbol, function, or organism across 250M+ entries from both TrEMBL (auto-annotated) and Swiss-Prot (manually curated)
Accession Lookup — Get complete protein data by UniProt accession number (e.g., P04637 for human p53) including function, subcellular location, and full amino acid sequence
Gene Search — Find all proteins encoded by a specific gene name across multiple organisms to compare orthologs and paralogs

The UniProt MCP Server exposes 3 tools through the Vinkius. Connect it to Google ADK in under two minutes — no API keys to rotate, no infrastructure to provision, no vendor lock-in. Your configuration, your data, your control.

How to Connect UniProt to Google ADK via MCP

Follow these steps to integrate the UniProt MCP Server with Google ADK.

Install Google ADK

Run pip install google-adk

Replace the token

Replace [YOUR_TOKEN_HERE] with your Vinkius token

Create the agent

Save the code above and integrate into your ADK workflow

Explore tools

The agent will discover 3 tools from UniProt via MCP

Why Use Google ADK with the UniProt MCP Server

Google ADK provides unique advantages when paired with UniProt through the Model Context Protocol.

Google ADK natively supports MCP tool servers — declare a tool provider and the framework handles discovery, validation, and execution

Built on Gemini models, ADK provides long-context reasoning ideal for complex multi-tool workflows with UniProt

Production-ready features like session management, evaluation, and deployment come built-in — not bolted on

Seamless integration with Google Cloud services means you can combine UniProt tools with BigQuery, Vertex AI, and Cloud Functions

UniProt + Google ADK Use Cases

Practical scenarios where Google ADK combined with the UniProt MCP Server delivers measurable value.

Enterprise data agents: ADK agents query UniProt and cross-reference results with internal databases for comprehensive analysis

Multi-modal workflows: combine UniProt tool responses with Gemini's vision and language capabilities in a single agent

Automated compliance checks: schedule ADK agents to query UniProt regularly and flag policy violations or configuration drift

Internal tool platforms: build self-service agent platforms where teams connect their own MCP servers including UniProt

UniProt MCP Tools for Google ADK (3)

These 3 tools become available when you connect UniProt to Google ADK via MCP:

get_uniprot_protein

Get full protein details by UniProt accession ID

search_uniprot

Returns protein name, gene, organism, function, subcellular location, and sequence. Try: insulin, hemoglobin, p53, BRCA1, spike protein. Search UniProt for proteins by name, function, or keyword

search_uniprot_gene

Returns all protein isoforms and their functional annotations. Find proteins encoded by a specific gene

Example Prompts for UniProt in Google ADK

Ready-to-use prompts you can give your Google ADK agent to start working with UniProt immediately.

"Tell me about the p53 tumor suppressor protein and its function."

"Find all proteins encoded by the BRCA1 gene."

"Look up UniProt accession Q9BYF1 and show me its full details."

Troubleshooting UniProt MCP Server with Google ADK

Common issues when connecting UniProt to Google ADK through the Vinkius, and how to resolve them.

McpToolset not found

Update: pip install --upgrade google-adk

UniProt + Google ADK FAQ

Common questions about integrating UniProt MCP Server with Google ADK.

How does Google ADK connect to MCP servers?

Import the MCP toolset class and pass the server URL. ADK discovers and registers all tools automatically, making them available to your agent's tool-use loop.

Can ADK agents use multiple MCP servers?

Yes. Declare multiple MCP tool providers in your agent configuration. ADK merges all tool schemas and the agent can call tools from any server in a single turn.

Which Gemini models work best with MCP tools?

Gemini 2.0 Flash and Pro models both support function calling required for MCP tools. Flash is recommended for latency-sensitive use cases, Pro for complex reasoning.