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How to Use the EBI InterPro MCP in Cline

Cline runs automated protein classification workflows using the EBI InterPro MCP Server.

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Cline

Connect EBI InterPro MCP to Cline

Create your Vinkius account to connect EBI InterPro to Cline and route execution through our secure gateway. The platform manages server hosting, runtime updates, and security layers. Configuration requires no manual server provisioning.

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End-to-end protein family classification

Cline uses `search_entries` to find relevant families based on your keywords. It then triggers `get_entry` to pull the full metadata, including Gene Ontology terms and literature counts. This allows you to automate the entire annotation process. Cline compiles the data into your project files, keeping your documentation accurate without manual copy-pasting.

Automated structural cross-referencing

When you need to verify a protein's structure, Cline executes `get_structure` with the target PDB ID. It maps the InterPro annotations onto the PDB data, giving you a complete view of the protein's functional sites. It handles the API calls and formats the output into readable reports. You define the sequence, and Cline builds the analysis.

Proteome-wide domain analysis

Give Cline a proteome ID, and it uses `get_proteome` to generate a summary of domain coverage. It processes the statistics for every protein associated with that organism. This tool is useful for batch-processing large datasets. Cline iterates through the results and flags proteins that match your specific functional criteria.

Setup guide

Set up EBI InterPro MCP in Cline

Prerequisites

  • VS Code with Cline extension installed
  • Active Vinkius subscription with a valid endpoint token
  1. 1

    Open Cline MCP settings

    Click the Cline icon in the VS Code sidebar to open the Cline panel. Then click the MCP Servers icon (server stack) at the top-right corner of the panel.

  2. 2

    Add a remote server

    Click "Remote Servers" at the top, then click "Add Remote MCP". In the Name field, type ebi-interpro-mcp. In the URL field, paste your Vinkius endpoint: https://edge.vinkius.com/[YOUR_TOKEN_HERE]/mcp. Get your token from cloud.vinkius.com.

  3. 3

    Enable the server

    After saving, the server appears in the Cline MCP panel. Toggle the switch to enable it. The status indicator turns green when the connection is live.

  4. 4

    Start using tools

    Return to the Cline chat and ask: "Check my latest EBI InterPro refund status." Cline will discover the available tools and request your approval before invoking each one — giving you full control over every action.

Cline MCP Settings
{
  "mcpServers": {
    "ebi-interpro-mcp": {
      "url": "https://edge.vinkius.com/[YOUR_TOKEN_HERE]/mcp"
    }
  }
}

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Common questions about EBI InterPro MCP in Cline

Go to the MCP Servers settings in the Cline sidebar. Add the server via the URL provided in your subscription, and Cline will auto-discover all 16 available tools.
Yes. Cline calls `search_taxonomy` to identify the correct taxon ID, then uses `get_entry_proteins` to list every member of a family within that organism.
Absolutely. Just instruct Cline to find the Pfam entry for your sequence. It will run `get_pfam_entry` and report back with the domain family details.
No. The server connects directly to the public EBI API. You just need to install the server and point Cline to the endpoint.
It accesses public protein sequences, domain families, and taxonomic data. The server does not handle any private or sensitive user-generated biological information.

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