EBI PDBe MCP Server for Vercel AI SDKGive Vercel AI SDK instant access to 16 tools to Get Assemblies, Get Binding Sites, Get Cofactors, and more
GDPR Free for SubscribersThe Vercel AI SDK is the TypeScript toolkit for building AI-powered applications. Connect EBI PDBe through Vinkius and every tool is available as a typed function. ready for React Server Components, API routes, or any Node.js backend.
Ask AI about this MCP Server for Vercel AI SDK
The EBI PDBe MCP Server for Vercel AI SDK is a standout in the The Unthinkable category — giving your AI agent 16 tools to work with, ready to go from day one.
Vinkius delivers Streamable HTTP and SSE to any MCP client
Geminiimport { createMCPClient } from "@ai-sdk/mcp";
import { generateText } from "ai";
import { openai } from "@ai-sdk/openai";
async function main() {
const mcpClient = await createMCPClient({
transport: {
type: "http",
// Your Vinkius token. get it at cloud.vinkius.com
url: "https://edge.vinkius.com/[YOUR_TOKEN_HERE]/mcp",
},
});
try {
const tools = await mcpClient.tools();
const { text } = await generateText({
model: openai("gpt-4o"),
tools,
prompt: "Using EBI PDBe, list all available capabilities.",
});
console.log(text);
} finally {
await mcpClient.close();
}
}
main();
* Every MCP server runs on Vinkius-managed infrastructure inside AWS - a purpose-built runtime with per-request V8 isolates, Ed25519 signed audit chains, and sub-40ms cold starts optimized for native MCP execution. See our infrastructure
About EBI PDBe MCP Server
Connect to the PDBe (Protein Data Bank in Europe) API and access the world's most comprehensive repository of experimentally determined 3D macromolecular structures.
The Vercel AI SDK gives every EBI PDBe tool full TypeScript type inference, IDE autocomplete, and compile-time error checking. Connect 16 tools through Vinkius and stream results progressively to React, Svelte, or Vue components. works on Edge Functions, Cloudflare Workers, and any Node.js runtime.
What you can do
- Structure Summaries — Get titles, authors, deposition dates, resolution, and experimental methods for any PDB entry
- Molecular Entities — Retrieve protein chains, nucleic acids, ligands, their sequences, source organisms, and gene names
- Binding Sites & Ligands — Access ligand binding pocket residues, small molecule ligands with formulas and weights
- Quality Assessment — Check resolution, R-factors, and overall quality scores for structure reliability
- UniProt Mappings — Map between UniProt sequence positions and PDB residue numbers
- Biological Assemblies — Understand quaternary structure — monomer, dimer, tetramer, or higher-order complexes
- Structure Search — Full-text Solr search across 200+ PDB metadata fields
- Publications — Find primary citations, PubMed IDs, and related structural studies
The EBI PDBe MCP Server exposes 16 tools through the Vinkius. Connect it to Vercel AI SDK in under two minutes — credentials fully managed, no infrastructure to provision, no vendor lock-in. Your configuration, your data, your control.
All 16 EBI PDBe tools available for Vercel AI SDK
When Vercel AI SDK connects to EBI PDBe through Vinkius, your AI agent gets direct access to every tool listed below — spanning pdb, protein-structure, 3d-structures, and more. Every call runs in a secure, isolated environment with full audit visibility. Beyond a simple connection, you get real-time monitoring of agent activity, enterprise governance, and optimized token usage.
Get assemblies on EBI PDBe
Returns assembly IDs, composition (which entities and how many copies), preferred assembly flag, and form description. Critical for understanding whether a protein functions as a monomer, dimer, tetramer, or higher-order complex. Get biological assembly information (quaternary structure)
Get binding sites on EBI PDBe
Critical for drug discovery, molecular docking, and understanding protein-ligand interactions. Get ligand binding site residues and interactions
Get cofactors on EBI PDBe
Cofactors like heme, NAD+, FAD, and metal ions are essential for enzyme catalysis and protein function. Get cofactor and prosthetic group annotations
Get experiment on EBI PDBe
Get experimental method details for a structure
Get ligand monomers on EBI PDBe
Returns chemical component IDs, names, molecular formulas, molecular weights, and their chain/residue positions. Essential for drug discovery and understanding protein-small molecule interactions. Get small molecule ligands bound in the structure
Get modified residues on EBI PDBe
Shows the parent compound ID and modification name. Get non-standard amino acids and nucleotides
Get molecules on EBI PDBe
Returns entity IDs, molecule types, names, chain assignments, sequence lengths, molecular weights, source organisms, and gene names. Get molecular entities (chains, polymers) in a structure
Get mutated residues on EBI PDBe
Shows the original residue, mutated residue, chain, and position. Essential for understanding how the crystallized construct differs from the native protein. Get engineered mutations vs. wild-type sequence
Get publications on EBI PDBe
Useful for finding the primary citation and methodology papers for a structure. Get associated journal publications and PubMed IDs
Get quality scores on EBI PDBe
The first thing a structural biologist checks when evaluating a structure for reliability. Get global quality metrics for a structure
Get related entries on EBI PDBe
Useful for discovering alternative conformations, mutants, or complexes of the same protein that have been structurally characterized. Get related PDB entries citing the same publications
Get residue listing on EBI PDBe
Shows residue names, numbers (both PDB and author numbering), organized by entity and chain. Returns a sample of the first 20 residues per chain for efficiency. Get full residue-level inventory per chain
Get secondary structure on EBI PDBe
Shows the count of helices and strands per chain, organized by molecular entity. Essential for understanding protein fold topology. Get helix, sheet, and coil assignments per residue
Get summary on EBI PDBe
Use a 4-character PDB ID such as 1cbs, 4hhb, 6lu7. Get PDB entry summary with title, authors, and resolution
Get uniprot mapping on EBI PDBe
Returns UniProt accessions, chain assignments, and start/end position mappings. Essential for cross-referencing between protein sequence databases and 3D structural data. Get UniProt to PDB residue mappings
Search structures on EBI PDBe
Use natural language queries like "insulin receptor kinase", "SARS-CoV-2 spike protein", "cryo-EM resolution<3", or specific organism names. Returns PDB IDs, titles, methods, resolutions, and organisms. Search PDB structures with full-text queries
Connect EBI PDBe to Vercel AI SDK via MCP
Follow these steps to wire EBI PDBe into Vercel AI SDK. The entire setup takes under two minutes — your credentials stay safe behind Vinkius.
Install dependencies
npm install @ai-sdk/mcp ai @ai-sdk/openaiReplace the token
[YOUR_TOKEN_HERE] with your Vinkius tokenRun the script
agent.ts and run with npx tsx agent.tsExplore tools
Why Use Vercel AI SDK with the EBI PDBe MCP Server
Vercel AI SDK provides unique advantages when paired with EBI PDBe through the Model Context Protocol.
TypeScript-first: every MCP tool gets full type inference, IDE autocomplete, and compile-time error checking out of the box
Framework-agnostic core works with Next.js, Nuxt, SvelteKit, or any Node.js runtime. same EBI PDBe integration everywhere
Built-in streaming UI primitives let you display EBI PDBe tool results progressively in React, Svelte, or Vue components
Edge-compatible: the AI SDK runs on Vercel Edge Functions, Cloudflare Workers, and other edge runtimes for minimal latency
EBI PDBe + Vercel AI SDK Use Cases
Practical scenarios where Vercel AI SDK combined with the EBI PDBe MCP Server delivers measurable value.
AI-powered web apps: build dashboards that query EBI PDBe in real-time and stream results to the UI with zero loading states
API backends: create serverless endpoints that orchestrate EBI PDBe tools and return structured JSON responses to any frontend
Chatbots with tool use: embed EBI PDBe capabilities into conversational interfaces with streaming responses and tool call visibility
Internal tools: build admin panels where team members interact with EBI PDBe through natural language queries
Example Prompts for EBI PDBe in Vercel AI SDK
Ready-to-use prompts you can give your Vercel AI SDK agent to start working with EBI PDBe immediately.
"Show me the structure summary and quality of the SARS-CoV-2 main protease (6lu7)."
"What ligands are bound in the hemoglobin structure 4hhb?"
"Search for cryo-EM structures of ribosome complexes."
Troubleshooting EBI PDBe MCP Server with Vercel AI SDK
Common issues when connecting EBI PDBe to Vercel AI SDK through Vinkius, and how to resolve them.
createMCPClient is not a function
npm install @ai-sdk/mcpEBI PDBe + Vercel AI SDK FAQ
Common questions about integrating EBI PDBe MCP Server with Vercel AI SDK.
How does the Vercel AI SDK connect to MCP servers?
createMCPClient from @ai-sdk/mcp and pass the server URL. The SDK discovers all tools and provides typed TypeScript interfaces for each one.Can I use MCP tools in Edge Functions?
Does it support streaming tool results?
useChat and streamText that handle tool calls and display results progressively in the UI.Explore More MCP Servers
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