EBI InterPro MCP Server for CrewAIGive CrewAI instant access to 16 tools to Get Cdd Entry, Get Clan, Get Entry, and more
GDPR Free for SubscribersConnect your CrewAI agents to EBI InterPro through Vinkius, pass the Edge URL in the `mcps` parameter and every EBI InterPro tool is auto-discovered at runtime. No credentials to manage, no infrastructure to maintain.
Ask AI about this MCP Server for CrewAI
The EBI InterPro MCP Server for CrewAI is a standout in the The Unthinkable category — giving your AI agent 16 tools to work with, ready to go from day one.
Vinkius delivers Streamable HTTP and SSE to any MCP client
Geminifrom crewai import Agent, Task, Crew
agent = Agent(
role="EBI InterPro Specialist",
goal="Help users interact with EBI InterPro effectively",
backstory=(
"You are an expert at leveraging EBI InterPro tools "
"for automation and data analysis."
),
# Your Vinkius token. get it at cloud.vinkius.com
mcps=["https://edge.vinkius.com/[YOUR_TOKEN_HERE]/mcp"],
)
task = Task(
description=(
"Explore all available tools in EBI InterPro "
"and summarize their capabilities."
),
agent=agent,
expected_output=(
"A detailed summary of 16 available tools "
"and what they can do."
),
)
crew = Crew(agents=[agent], tasks=[task])
result = crew.kickoff()
print(result)
* Every MCP server runs on Vinkius-managed infrastructure inside AWS - a purpose-built runtime with per-request V8 isolates, Ed25519 signed audit chains, and sub-40ms cold starts optimized for native MCP execution. See our infrastructure
About EBI InterPro MCP Server
Connect to the InterPro API and access the world's most comprehensive resource for protein family, domain, and functional site classification.
When paired with CrewAI, EBI InterPro becomes a first-class tool in your multi-agent workflows. Each agent in the crew can call EBI InterPro tools autonomously, one agent queries data, another analyzes results, a third compiles reports, all orchestrated through Vinkius with zero configuration overhead.
What you can do
- Domain Classification — Retrieve detailed InterPro entry information including family/domain descriptions, GO terms, and member database cross-references
- Multi-Database Access — Query entries from Pfam, CDD, SMART, Prosite, PANTHER, Gene3D, HAMAP, and more through a unified interface
- Protein Annotation — Find all InterPro domains, families, and sites annotated on any UniProt protein
- Structure Mapping — Discover PDB structures containing proteins that match specific InterPro entries
- Taxonomic Distribution — Explore which organisms contain proteins matching a domain or family — essential for evolutionary biology
- Proteome Coverage — Assess domain annotation coverage for complete proteomes
- Clan Analysis — Navigate Pfam clan hierarchies to understand super-family relationships
The EBI InterPro MCP Server exposes 16 tools through the Vinkius. Connect it to CrewAI in under two minutes — credentials fully managed, no infrastructure to provision, no vendor lock-in. Your configuration, your data, your control.
All 16 EBI InterPro tools available for CrewAI
When CrewAI connects to EBI InterPro through Vinkius, your AI agent gets direct access to every tool listed below — spanning interpro, pfam, protein-domains, and more. Every call runs in a secure, isolated environment with full audit visibility. Beyond a simple connection, you get real-time monitoring of agent activity, enterprise governance, and optimized token usage.
Get cdd entry on EBI InterPro
CDD provides curated models for protein domain families and includes additional alignment and structure data. Use accessions like cd00001. Get CDD (Conserved Domain Database) entry details
Get clan on EBI InterPro
Returns clan accession, name, description, and member counts. Use Pfam clan accessions like CL0001. Get Pfam clan (super-family grouping) details
Get entry on EBI InterPro
Returns name, type (family, domain, homologous superfamily, repeat, site), description, Gene Ontology terms, member database cross-references, and literature count. Use accessions like IPR000001, IPR036291. Get InterPro entry metadata for a family or domain
Get entry proteins on EBI InterPro
Returns protein accessions, names, lengths, and source organisms. Useful for finding all members of a protein family across the UniProt database. Get all proteins matching an InterPro entry
Get entry structures on EBI InterPro
Returns PDB IDs, names, experiment types, and resolutions. Useful for finding structural representatives of a protein family or domain. Get all PDB structures matching an InterPro entry
Get entry taxonomy on EBI InterPro
Returns taxonomy nodes with names, ranks, and protein counts. This answers the evolutionary biology question "which organisms have this domain/family?" and is essential for understanding protein evolution and conservation. Get taxonomic distribution of an InterPro entry
Get pfam entry on EBI InterPro
Pfam is the most widely used protein domain database. Use accessions like PF00069 (kinase domain), PF00076 (RRM domain). Get Pfam domain or family details
Get protein on EBI InterPro
Returns the protein name, length, source organism, evidence level, fragment status, and counters for how many InterPro entries, Pfam domains, structures, and taxa are associated with it. Get protein details with all domain and family assignments
Get protein entries on EBI InterPro
This is the key tool for understanding "what domains does my protein have?" — the fundamental question in protein characterization. Get all InterPro entries matching a specific protein
Get proteome on EBI InterPro
Returns proteome ID, organism name, strain, reference status, and counters for associated entries and proteins. Use UniProt proteome IDs like UP000005640 (human). Get proteome details with domain coverage statistics
Get structure on EBI InterPro
Use a 4-character PDB ID like 1cbs or 4hhb. Get a PDB structure with mapped InterPro annotations
Get taxonomy on EBI InterPro
Returns the organism name, rank, lineage, number of children taxa, and counters for associated InterPro entries and proteins. Use IDs like 9606 (human), 10090 (mouse), 562 (E. coli). Get taxonomic node with entry and protein counts
List entry databases on EBI InterPro
Shows the number of entries in each database. Useful for understanding the scope of available domain and family annotations. List all InterPro member databases and entry counts
Search entries on EBI InterPro
Optionally filter by entry type: family, domain, homologous_superfamily, repeat, or site. Returns accessions, names, types, and protein/structure counts. Use queries like "kinase", "zinc finger", "immunoglobulin". Search InterPro entries by keyword and type
Search proteins on EBI InterPro
Returns UniProt accessions, names, lengths, organisms, and annotation counts. Use queries like "insulin", "hemoglobin", "BRCA1". Search proteins in InterPro by name or keyword
Search taxonomy on EBI InterPro
Returns taxon IDs, names, ranks, and annotation counts. Use queries like "human", "drosophila", "arabidopsis", "saccharomyces". Search taxonomy by organism name
Connect EBI InterPro to CrewAI via MCP
Follow these steps to wire EBI InterPro into CrewAI. The entire setup takes under two minutes — your credentials stay safe behind Vinkius.
Install CrewAI
pip install crewaiReplace the token
[YOUR_TOKEN_HERE] with your Vinkius token from cloud.vinkius.comCustomize the agent
role, goal, and backstory to fit your use caseRun the crew
python crew.py. CrewAI auto-discovers 16 tools from EBI InterProWhy Use CrewAI with the EBI InterPro MCP Server
CrewAI Multi-Agent Orchestration Framework provides unique advantages when paired with EBI InterPro through the Model Context Protocol.
Multi-agent collaboration lets you decompose complex workflows into specialized roles, one agent researches, another analyzes, a third generates reports, each with access to MCP tools
CrewAI's native MCP integration requires zero adapter code: pass Vinkius Edge URL directly in the `mcps` parameter and agents auto-discover every available tool at runtime
Built-in task delegation and shared memory mean agents can pass context between steps without manual state management, enabling multi-hop reasoning across tool calls
Sequential and hierarchical crew patterns map naturally to real-world workflows: enumerate subdomains → analyze DNS history → check WHOIS records → compile findings into actionable reports
EBI InterPro + CrewAI Use Cases
Practical scenarios where CrewAI combined with the EBI InterPro MCP Server delivers measurable value.
Automated multi-step research: a reconnaissance agent queries EBI InterPro for raw data, then a second analyst agent cross-references findings and flags anomalies. all without human handoff
Scheduled intelligence reports: set up a crew that periodically queries EBI InterPro, analyzes trends over time, and generates executive briefings in markdown or PDF format
Multi-source enrichment pipelines: chain EBI InterPro tools with other MCP servers in the same crew, letting agents correlate data across multiple providers in a single workflow
Compliance and audit automation: a compliance agent queries EBI InterPro against predefined policy rules, generates deviation reports, and routes findings to the appropriate team
Example Prompts for EBI InterPro in CrewAI
Ready-to-use prompts you can give your CrewAI agent to start working with EBI InterPro immediately.
"What domains and families does the human TP53 protein belong to?"
"Show me all member databases in InterPro and how many entries each has."
"Which organisms have the kinase domain PF00069?"
Troubleshooting EBI InterPro MCP Server with CrewAI
Common issues when connecting EBI InterPro to CrewAI through Vinkius, and how to resolve them.
MCP tools not discovered
Agent not using tools
Timeout errors
Rate limiting or 429 errors
EBI InterPro + CrewAI FAQ
Common questions about integrating EBI InterPro MCP Server with CrewAI.
How does CrewAI discover and connect to MCP tools?
tools/list method. This means tools are always fresh and reflect the server's current capabilities. No tool schemas need to be hardcoded.Can different agents in the same crew use different MCP servers?
mcps list, so you can assign specific servers to specific roles. For example, a reconnaissance agent might use a domain intelligence server while an analysis agent uses a vulnerability database server.What happens when an MCP tool call fails during a crew run?
Can CrewAI agents call multiple MCP tools in parallel?
process=Process.parallel, each calling different MCP tools concurrently. This is ideal for workflows where separate data sources need to be queried simultaneously.Can I run CrewAI crews on a schedule (cron)?
crew.kickoff() method runs synchronously by default, making it straightforward to integrate into existing pipelines.Explore More MCP Servers
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