EBI InterPro MCP Server for LangChainGive LangChain instant access to 16 tools to Get Cdd Entry, Get Clan, Get Entry, and more

Name: EBI InterPro
Price: 29 USD
Availability: InStock
Rating: 4.9 (1 reviews)
Author: Vinkius

GDPR Free for Subscribers

LangChain is the leading Python framework for composable LLM applications. Connect EBI InterPro through Vinkius and LangChain agents can call every tool natively. combine them with retrievers, memory, and output parsers for sophisticated AI pipelines.

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The EBI InterPro MCP Server for LangChain is a standout in the The Unthinkable category — giving your AI agent 16 tools to work with, ready to go from day one.

Built for AI Agents by Vinkius

Vinkius delivers Streamable HTTP and SSE to any MCP client

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python

import asyncio
from langchain_mcp_adapters.client import MultiServerMCPClient
from langchain_openai import ChatOpenAI
from langgraph.prebuilt import create_react_agent

async def main():
    # Your Vinkius token. get it at cloud.vinkius.com
    async with MultiServerMCPClient({
        "ebi-interpro": {
            "transport": "streamable_http",
            "url": "https://edge.vinkius.com/[YOUR_TOKEN_HERE]/mcp",
        }
    }) as client:
        tools = client.get_tools()
        agent = create_react_agent(
            ChatOpenAI(model="gpt-4o"),
            tools,
        )
        response = await agent.ainvoke({
            "messages": [{
                "role": "user",
                "content": "Using EBI InterPro, show me what tools are available.",
            }]
        })
        print(response["messages"][-1].content)

asyncio.run(main())

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About EBI InterPro MCP Server

Connect to the InterPro API and access the world's most comprehensive resource for protein family, domain, and functional site classification.

LangChain's ecosystem of 500+ components combines seamlessly with EBI InterPro through native MCP adapters. Connect 16 tools via Vinkius and use ReAct agents, Plan-and-Execute strategies, or custom agent architectures. with LangSmith tracing giving full visibility into every tool call, latency, and token cost.

What you can do

Domain Classification — Retrieve detailed InterPro entry information including family/domain descriptions, GO terms, and member database cross-references
Multi-Database Access — Query entries from Pfam, CDD, SMART, Prosite, PANTHER, Gene3D, HAMAP, and more through a unified interface
Protein Annotation — Find all InterPro domains, families, and sites annotated on any UniProt protein
Structure Mapping — Discover PDB structures containing proteins that match specific InterPro entries
Taxonomic Distribution — Explore which organisms contain proteins matching a domain or family — essential for evolutionary biology
Proteome Coverage — Assess domain annotation coverage for complete proteomes
Clan Analysis — Navigate Pfam clan hierarchies to understand super-family relationships

The EBI InterPro MCP Server exposes 16 tools through the Vinkius. Connect it to LangChain in under two minutes — credentials fully managed, no infrastructure to provision, no vendor lock-in. Your configuration, your data, your control.

All 16 EBI InterPro tools available for LangChain

When LangChain connects to EBI InterPro through Vinkius, your AI agent gets direct access to every tool listed below — spanning interpro, pfam, protein-domains, and more. Every call runs in a secure, isolated environment with full audit visibility. Beyond a simple connection, you get real-time monitoring of agent activity, enterprise governance, and optimized token usage.

get

Get cdd entry on EBI InterPro

CDD provides curated models for protein domain families and includes additional alignment and structure data. Use accessions like cd00001. Get CDD (Conserved Domain Database) entry details

get

Get clan on EBI InterPro

Returns clan accession, name, description, and member counts. Use Pfam clan accessions like CL0001. Get Pfam clan (super-family grouping) details

get

Get entry on EBI InterPro

Returns name, type (family, domain, homologous superfamily, repeat, site), description, Gene Ontology terms, member database cross-references, and literature count. Use accessions like IPR000001, IPR036291. Get InterPro entry metadata for a family or domain

get

Get entry proteins on EBI InterPro

Returns protein accessions, names, lengths, and source organisms. Useful for finding all members of a protein family across the UniProt database. Get all proteins matching an InterPro entry

get

Get entry structures on EBI InterPro

Returns PDB IDs, names, experiment types, and resolutions. Useful for finding structural representatives of a protein family or domain. Get all PDB structures matching an InterPro entry

get

Get entry taxonomy on EBI InterPro

Returns taxonomy nodes with names, ranks, and protein counts. This answers the evolutionary biology question "which organisms have this domain/family?" and is essential for understanding protein evolution and conservation. Get taxonomic distribution of an InterPro entry

get

Get pfam entry on EBI InterPro

Pfam is the most widely used protein domain database. Use accessions like PF00069 (kinase domain), PF00076 (RRM domain). Get Pfam domain or family details

get

Get protein on EBI InterPro

Returns the protein name, length, source organism, evidence level, fragment status, and counters for how many InterPro entries, Pfam domains, structures, and taxa are associated with it. Get protein details with all domain and family assignments

get

Get protein entries on EBI InterPro

This is the key tool for understanding "what domains does my protein have?" — the fundamental question in protein characterization. Get all InterPro entries matching a specific protein

get

Get proteome on EBI InterPro

Returns proteome ID, organism name, strain, reference status, and counters for associated entries and proteins. Use UniProt proteome IDs like UP000005640 (human). Get proteome details with domain coverage statistics

get

Get structure on EBI InterPro

Use a 4-character PDB ID like 1cbs or 4hhb. Get a PDB structure with mapped InterPro annotations

get

Get taxonomy on EBI InterPro

Returns the organism name, rank, lineage, number of children taxa, and counters for associated InterPro entries and proteins. Use IDs like 9606 (human), 10090 (mouse), 562 (E. coli). Get taxonomic node with entry and protein counts

list

List entry databases on EBI InterPro

Shows the number of entries in each database. Useful for understanding the scope of available domain and family annotations. List all InterPro member databases and entry counts

Search entries on EBI InterPro

Optionally filter by entry type: family, domain, homologous_superfamily, repeat, or site. Returns accessions, names, types, and protein/structure counts. Use queries like "kinase", "zinc finger", "immunoglobulin". Search InterPro entries by keyword and type

Search proteins on EBI InterPro

Returns UniProt accessions, names, lengths, organisms, and annotation counts. Use queries like "insulin", "hemoglobin", "BRCA1". Search proteins in InterPro by name or keyword

Search taxonomy on EBI InterPro

Returns taxon IDs, names, ranks, and annotation counts. Use queries like "human", "drosophila", "arabidopsis", "saccharomyces". Search taxonomy by organism name

Connect EBI InterPro to LangChain via MCP

Follow these steps to wire EBI InterPro into LangChain. The entire setup takes under two minutes — your credentials stay safe behind Vinkius.

Install dependencies

Run pip install langchain langchain-mcp-adapters langgraph langchain-openai

Replace the token

Replace [YOUR_TOKEN_HERE] with your Vinkius token

Run the agent

Save the code and run python agent.py

Explore tools

The agent discovers 16 tools from EBI InterPro via MCP

Why Use LangChain with the EBI InterPro MCP Server

LangChain provides unique advantages when paired with EBI InterPro through the Model Context Protocol.

The largest ecosystem of integrations, chains, and agents. combine EBI InterPro MCP tools with 500+ LangChain components

Agent architecture supports ReAct, Plan-and-Execute, and custom strategies with full MCP tool access at every step

LangSmith tracing gives you complete visibility into tool calls, latencies, and token usage for production debugging

Memory and conversation persistence let agents maintain context across EBI InterPro queries for multi-turn workflows

EBI InterPro + LangChain Use Cases

Practical scenarios where LangChain combined with the EBI InterPro MCP Server delivers measurable value.

RAG with live data: combine EBI InterPro tool results with vector store retrievals for answers grounded in both real-time and historical data

Autonomous research agents: LangChain agents query EBI InterPro, synthesize findings, and generate comprehensive research reports

Multi-tool orchestration: chain EBI InterPro tools with web scrapers, databases, and calculators in a single agent run

Production monitoring: use LangSmith to trace every EBI InterPro tool call, measure latency, and optimize your agent's performance

Example Prompts for EBI InterPro in LangChain

Ready-to-use prompts you can give your LangChain agent to start working with EBI InterPro immediately.

"What domains and families does the human TP53 protein belong to?"

"Show me all member databases in InterPro and how many entries each has."

"Which organisms have the kinase domain PF00069?"

Troubleshooting EBI InterPro MCP Server with LangChain

Common issues when connecting EBI InterPro to LangChain through Vinkius, and how to resolve them.

MultiServerMCPClient not found

Install: pip install langchain-mcp-adapters

EBI InterPro + LangChain FAQ

Common questions about integrating EBI InterPro MCP Server with LangChain.

How does LangChain connect to MCP servers?

Use langchain-mcp-adapters to create an MCP client. LangChain discovers all tools and wraps them as native LangChain tools compatible with any agent type.

Which LangChain agent types work with MCP?

All agent types including ReAct, OpenAI Functions, and custom agents work with MCP tools. The tools appear as standard LangChain tools after the adapter wraps them.